通过对分离出的肝素进行亚硝酸解聚获得的肝素寡糖微阵列。

Microarrays of heparin oligosaccharides obtained by nitrous acid depolymerization of isolated heparin.

作者信息

de Paz Jose L, Spillmann Dorothe, Seeberger Peter H

机构信息

Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zürich, Wolfgang-Pauli-Str. 10, HCI F315, 8093, Zürich, Switzerland.

出版信息

Chem Commun (Camb). 2006 Aug 7(29):3116-8. doi: 10.1039/b605318a. Epub 2006 Jun 14.

DOI:10.1039/b605318a

PMID:16855704

Abstract

Heparin oligosaccharides derived by nitrous acid depolymerization of heparin have been immobilized on amine-coated glass slides. The formation of a Schiff base creates heparin chips that are a suitable platform for the high-throughput analysis of carbohydrate-protein interactions.

摘要

通过肝素的亚硝酸解聚得到的肝素寡糖已被固定在胺涂层载玻片上。席夫碱的形成产生了肝素芯片，它是用于碳水化合物-蛋白质相互作用高通量分析的合适平台。