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抗精神病药恶性综合征的药物治疗。

Drug treatment of the neuroleptic malignant syndrome.

作者信息

Sakkas P, Davis J M, Janicak P G, Wang Z Y

机构信息

Illinois State Psychiatric Institute, Chicago.

出版信息

Psychopharmacol Bull. 1991;27(3):381-4.

PMID:1685592
Abstract

We performed a case-controlled analysis on the effectiveness of dantrolene and certain dopamine agonists--bromocriptine, amantadine 3,4-dihydroxyphenylalanine, (DOPA)--for the neuroleptic malignant syndrome (NMS). This was based on a review of all known published studies using as controls those cases not treated with these drugs and/or electroconvulsive therapy. In this control group, the NMS-related death rate was 21 percent. Dantrolene alone reduced the death rate to 8.6 percent, bromocriptine alone to 7.8 percent, and amantadine alone to 5.9 percent. We also stratified patients into five levels of severity based on state of consciousness and temperature and showed that the relative reduction in death rate held up at all levels. The dopamine agonists and dantrolene have a therapeutic effect independent of each other.

摘要

我们对丹曲林及某些多巴胺激动剂——溴隐亭、金刚烷胺、3,4-二羟基苯丙氨酸(多巴)——治疗抗精神病药恶性综合征(NMS)的有效性进行了病例对照分析。这是基于对所有已知已发表研究的回顾,这些研究将未接受这些药物治疗和/或电休克治疗的病例用作对照。在这个对照组中,与NMS相关的死亡率为21%。单独使用丹曲林可将死亡率降至8.6%,单独使用溴隐亭降至7.8%,单独使用金刚烷胺降至5.9%。我们还根据意识状态和体温将患者分为五个严重程度级别,并表明在所有级别中死亡率的相对降低都成立。多巴胺激动剂和丹曲林具有相互独立的治疗作用。

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