Bogaert Elke, Van Damme Philip, Van Den Bosch Ludo, Robberecht Wim
Laboratory of Neurobiology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.
Muscle Nerve. 2006 Oct;34(4):391-405. doi: 10.1002/mus.20609.
The angiogenic activity of vascular endothelial growth factor (VEGF) is well known. Recently, it has become evident that VEGF is involved in central nervous system physiology and may play a role in the pathogenesis of neurological diseases. In particular, it may be involved in the mechanism of motor neuron degeneration in amyotrophic lateral sclerosis (ALS), and has been hypothesized to be implicated in the pathogenesis of peripheral neuropathies such as occur in the so-called POEMS syndrome and diabetes. VEGF is also being studied as a possible treatment option in some of these disorders. In this review we critically analyze the data supporting the notion that VEGF is a factor involved in motor neuron degeneration and review the studies linking VEGF to other diseases of the peripheral and central nervous systems.
血管内皮生长因子（VEGF）的血管生成活性是众所周知的。最近，有证据表明VEGF参与中枢神经系统生理过程，可能在神经疾病的发病机制中发挥作用。特别是，它可能参与肌萎缩侧索硬化症（ALS）中运动神经元变性的机制，并被推测与诸如所谓的POEMS综合征和糖尿病中出现的周围神经病变的发病机制有关。VEGF也正在作为这些疾病的一种可能治疗选择进行研究。在这篇综述中，我们批判性地分析了支持VEGF是参与运动神经元变性这一观点的数据，并回顾了将VEGF与周围和中枢神经系统的其他疾病联系起来的研究。
