共轭亚油酸是大鼠的一种生长因子，表现为体重增加加快和饲料效率提高。

Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency.

作者信息

Chin S F, Storkson J M, Albright K J, Cook M E, Pariza M W

机构信息

Food Research Institute, Department of Food Microbiology and Toxicology, University of Wisconsin-Madison, Madison, WI 53706, USA.

出版信息

J Nutr. 1994 Dec;124(12):2344-9. doi: 10.1093/jn/124.12.344.

DOI:10.1093/jn/124.12.344

PMID:16856314

Abstract

We studied the effect of conjugated linoleic acid (CLA) on rat development and growth. Primigravid female Fischer rats were fed control or CLA-supplemented (0.25% or 0.5% CLA) diets during gestation and/or lactation. Conjugated linoleic acid was incorporated into milk fat and tissue lipids proportional to the level of CLA fed and the duration of CLA feeding. Conjugated linoleic acid was incorporated into fetal and neonatal tissues; it did not affect litter size nor induce apparent abnormalities. To the contrary, feeding CLA to the dams during gestation and lactation improved the postnatal body weight gain of pups (P < 0.05), measured on d 10 of lactation. Pups that continued to receive the CLA-supplemented diet after weaning had significantly greater body weight gain and improved feed efficiency relative to control animals (P < 0.05).

摘要

我们研究了共轭亚油酸（CLA）对大鼠发育和生长的影响。初孕雌性Fischer大鼠在妊娠和/或哺乳期喂食对照饮食或补充CLA（0.25%或0.5% CLA）的饮食。共轭亚油酸按喂食CLA的水平和喂食CLA的持续时间成比例地掺入乳脂肪和组织脂质中。共轭亚油酸被掺入胎儿和新生儿组织中；它不影响窝仔数，也未诱发明显异常。相反，在妊娠和哺乳期给母鼠喂食CLA可改善幼崽出生后的体重增加（P < 0.05），这是在哺乳期第10天测量的。断奶后继续接受补充CLA饮食的幼崽相对于对照动物体重增加显著更大，饲料效率也有所提高（P < 0.05）。