Lewinson Oded, Adler Julia, Sigal Nadejda, Bibi Eitan
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel.
Mol Microbiol. 2006 Jul;61(2):277-84. doi: 10.1111/j.1365-2958.2006.05254.x.
Multidrug (Mdr) transport is an obstacle to the successful treatment of cancer and infectious diseases, and it is mediated by Mdr transporters that recognize and export an unusually broad spectrum of chemically dissimilar toxic compounds. Therefore, in addition to its clinical significance, the Mdr transport phenomenon presents intriguing and challenging mechanistic queries. Recent studies of secondary Mdr transporters of the major facilitator superfamily (MFS) have revealed that they are promiscuous not only regarding their substrate recognition profile, but also with respect to matters of energy utilization, electrical and chemical flexibility in the Mdr recognition pocket, and surprisingly, also in their physiological functions.
多药耐药（Mdr）转运是癌症和传染病成功治疗的一个障碍，它由Mdr转运蛋白介导，这些转运蛋白能识别并输出异常广泛的化学性质不同的有毒化合物。因此，除了其临床意义外，Mdr转运现象还提出了有趣且具有挑战性的机制问题。最近对主要易化子超家族（MFS）的次级Mdr转运蛋白的研究表明，它们不仅在底物识别方面具有混杂性，而且在能量利用、Mdr识别口袋中的电和化学灵活性方面，以及令人惊讶的是，在其生理功能方面也具有混杂性。
