酪氨酸羟化酶基因多态性与双相情感障碍

Tyrosine hydroxylase polymorphisms and bipolar affective disorder.

作者信息

Gill M, Castle D, Hunt N, Clements A, Sham P, Murray R M

机构信息

Genetics Section, Institute of Psychiatry, London, U.K.

出版信息

J Psychiatr Res. 1991;25(4):179-84. doi: 10.1016/0022-3956(91)90022-3.

DOI:10.1016/0022-3956(91)90022-3

PMID:1685750

Abstract

A reported genetic association between bipolar affective disorder and DNA polymorphisms at the tyrosine hydroxylase gene is not confirmed by the present study. The combined allele frequencies in the patients, from studies published to date, are significantly different from the frequencies in the controls for the TY7/BglII polymorphism.

摘要

本研究未证实双相情感障碍与酪氨酸羟化酶基因的DNA多态性之间存在已报道的遗传关联。就TY7/BglII多态性而言，从迄今发表的研究来看，患者的合并等位基因频率与对照组的频率存在显著差异。