双相情感障碍与酪氨酸羟化酶DNA标记之间不存在关联。
Lack of association between bipolar affective disorder and tyrosine hydroxylase DNA marker.
作者信息
Inayama Y, Yoneda H, Sakai T, Ishida T, Kobayashi S, Nonomura Y, Kono Y, Koh J, Asaba H
机构信息
Department of Neuropsychiatry, Osaka Medical College, Japan.
出版信息
Am J Med Genet. 1993 Jul 15;48(2):87-9. doi: 10.1002/ajmg.1320480206.
PMID:8103293
Abstract
Sixty-eight patients with bipolar affective disorder and 88 controls were investigated for genetic association of tyrosine hydroxylase (TH) restriction fragment length polymorphisms (RFLPs). No significant association between bipolar affective disorder and TH was found. Thus the hypothesis that TH is involved in the pathogenesis of bipolar affective disorder was not supported.
摘要
对68例双相情感障碍患者和88名对照者进行了酪氨酸羟化酶（TH）限制性片段长度多态性（RFLP）的基因关联研究。未发现双相情感障碍与TH之间存在显著关联。因此，TH参与双相情感障碍发病机制的假说未得到支持。
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