Martínez de Gereñu Alonso M A, Castells Armenter M V, Gargallo López C M, Peña García L
Servicio de Anestesiología y Reanimación, Hospital 12 de Octubre, Madrid.
Rev Esp Anestesiol Reanim. 1991 Sep-Oct;38(5):338-40.
Muscular relaxant vecuronium bromide (Norcuron R, Organon Teknika Española, S.A.) was administered to 20 patients undergoing intracranial surgery with general anesthesia at a dose of 0.01 mg/kg weight followed by 0.1 mg/kg (intubation dose) four minutes later. Two minutes after the second dose and under careful manual mechanical ventilation with O2 100%, a laryngoscopy was performed to evaluate the conditions for intubation. Mean arterial pressure, heart rate, PaO2, and PaCO2 were measured at baseline and immediately before laryngoscopy. Neuromuscular function was monitored observing the response to a train of four stimuli applied on the cubital nerve. During the operation a continuous infusion of vecuronium at a rate of 1 microgram/kg/min was maintained. Conditions for intubation were excellent in 18 patients and good in two cases. Mean heart rate and PaCO2 did not show significant variations. In contrast, during prelaryngoscopy mean arterial pressure decreased and PaO2 increased with respect to the baseline values. During surgery all patients showed a good clinical relaxation. Thus, we believe that vecuronium is a good muscular relaxant agent, safe, and effective to be used in neurosurgery.
将肌肉松弛剂维库溴铵（诺库隆R，西班牙欧加农公司）以0.01毫克/千克体重的剂量给予20例接受全身麻醉的颅内手术患者，4分钟后再给予0.1毫克/千克（插管剂量）。在第二次给药后2分钟，在100%氧气的仔细手动机械通气下，进行喉镜检查以评估插管条件。在基线和喉镜检查前即刻测量平均动脉压、心率、动脉血氧分压（PaO2）和动脉血二氧化碳分压（PaCO2）。通过观察对施加于肘神经的四个成串刺激的反应来监测神经肌肉功能。手术期间以1微克/千克/分钟的速率持续输注维库溴铵。18例患者的插管条件极佳，2例良好。平均心率和PaCO2未显示出明显变化。相比之下，在喉镜检查前，平均动脉压相对于基线值下降，PaO2升高。手术期间所有患者均表现出良好的临床松弛状态。因此，我们认为维库溴铵是一种良好的肌肉松弛剂，在神经外科手术中使用安全且有效。
