Kunjappan V E, Brown E M, Alexander G D
Anesth Analg. 1986 May;65(5):503-6.
The purpose of this study was to determine the ideal priming and total dose of vecuronium when used as the relaxant during rapid sequence induction of anesthesia and tracheal intubation. Seventy patients were studied. Various priming and total dose schedules using vecuronium were compared with succinylcholine, 1.5 mg/kg. The mean onset times, intubating conditions, and mean duration times were compared. A priming dose of 10 micrograms/kg produced good intubation conditions with both 70 micrograms/kg and 150 micrograms/kg (total doses), but the mean onset times remained significantly longer than succinylcholine 1.5 mg/kg (P less than 0.05). A priming dose of 15 micrograms/kg of vecuronium with 100 micrograms/kg total dose, on the other hand, not only produced excellent intubating conditions but also resulted in a mean onset time not significantly different from succinylcholine, 1.5 mg/kg. This latter dose schedule of vecuronium is recommended for rapid sequence induction when succinylcholine is contraindicated. Vecuronium is preferable to pancuronium for rapid sequence induction because of its lack of cardiovascular side effects and short duration.
本研究的目的是确定维库溴铵在麻醉快速顺序诱导和气管插管期间用作肌松药时的理想预注剂量和总剂量。对70例患者进行了研究。将使用维库溴铵的各种预注和总剂量方案与1.5mg/kg的琥珀胆碱进行比较。比较了平均起效时间、插管条件和平均持续时间。10μg/kg的预注剂量与70μg/kg和150μg/kg（总剂量）均产生了良好的插管条件，但平均起效时间仍显著长于1.5mg/kg的琥珀胆碱（P<0.05）。另一方面，15μg/kg的维库溴铵预注剂量与100μg/kg的总剂量，不仅产生了极佳的插管条件，而且平均起效时间与1.5mg/kg的琥珀胆碱无显著差异。当琥珀胆碱禁忌时，推荐维库溴铵的后一种剂量方案用于快速顺序诱导。由于维库溴铵缺乏心血管副作用且作用持续时间短，因此在快速顺序诱导中比泮库溴铵更可取。
