表皮内和真皮内侵袭性小汗腺导管癌的角蛋白谱可能有所不同。
Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma.
作者信息
Kurokawa Ichiro, Urakawa Yoshiko, Senba Yuko, Kawabata Eriko, Nishimura Keisuke, Omoto Youichi, Tokime Kazuya, Mizutani Hitoshi, Tsubura Airo
机构信息
Department of Dermatology, Mie University Graduate School of Medicine, Mie 514-8507, Japan.
出版信息
Oncol Rep. 2006 Sep;16(3):473-7.
We report two cases of eccrine porocarcinoma (EPC), one of intrepidermal EPC (IEEPC) and one of intradermal invasive EPC (IDEPC) in an immunohistochemical study of cytokeratins (CK) using nine different anti-keratin antibodies against CK1, 7, 8, 10, 14, 16, 17, 18 and 19. IEEPC expressed terminal differentiated CK1 and CK10. In contrast, IDEPC expressed simple-epithelial keratins such as CK7, 8, 18 and 19. Keratin expression of IEEPC preserves the immunophenotypes of normal epidermis. IDEPC, however, expresses poorly differentiated keratin. These results suggest that the keratin profiles of EPC are correlated with the invasive degree and reflect the clinical prognosis of EPC.
我们报告了两例小汗腺汗孔癌（EPC），其中一例为表皮内小汗腺汗孔癌（IEEPC），另一例为真皮内浸润性小汗腺汗孔癌（IDEPC），这是一项使用九种不同的抗角蛋白抗体（针对CK1、7、8、10、14、16、17、18和19）对角蛋白（CK）进行免疫组织化学研究的结果。IEEPC表达终末分化的CK1和CK10。相比之下，IDEPC表达简单上皮角蛋白，如CK7、8、18和19。IEEPC的角蛋白表达保留了正常表皮的免疫表型。然而，IDEPC表达低分化角蛋白。这些结果表明，EPC的角蛋白谱与浸润程度相关，并反映了EPC的临床预后。
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