Ehara Yuko, Goto Hiroyuki, Ozaki Kanae, Yoshida Yuichi
Division of Dermatology, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.
Department of Pathology, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.
Yonago Acta Med. 2023 Jul 25;66(3):382-384. doi: 10.33160/yam.2023.08.005. eCollection 2023 Aug.
Psoriasis is a common chronical inflammatory skin disease with a prevalence of 2%-4% worldwide. In contrast, porocarcinoma is a relatively rare cutaneous neoplasm and an associated localization of both lesions is rare. Here, we describe the first case of porocarcinoma in a patient with psoriasis. A 71-year-old Japanese man was referred to our clinic for evaluation of nodule within a keratotic plaque of 20-years history on his leg. Histopathological examination showed that the plaque revealed acanthosis with regular elongation of rete ridges, agranulosis and the presence of Munro microabscesses. In contrast, massive proliferation of atypical poroid cells and a few cuticular cells in the dermis were seen in the nodule. We speculated that it is likely the porocarcinoma was caused by the elevated risk of skin cancer due to chronic inflammatory process of psoriasis itself in our patient.
银屑病是一种常见的慢性炎症性皮肤病，在全球的患病率为2%-4%。相比之下，汗孔癌是一种相对罕见的皮肤肿瘤，两种病变相关的定位很少见。在此，我们描述了首例合并银屑病的汗孔癌患者。一名71岁的日本男性因腿部有20年病史的角化性斑块内的结节前来我院评估。组织病理学检查显示，斑块表现为棘层肥厚， rete嵴规则延长，无颗粒层，有Munro微脓肿。相比之下，在结节中可见真皮内非典型汗孔样细胞和一些角质形成细胞的大量增殖。我们推测，在我们的患者中，汗孔癌可能是由于银屑病本身的慢性炎症过程导致皮肤癌风险升高所致。
