Merle Patrick, Morvan Daniel, Madelmont Jean Claude, Caillaud Denis, Demidem Aicha
CHU Clermont-Ferrand, Service de Pneumologie, Hôpital Gabriel Montpied, F63001 Clermont-Ferrand, France.
Int J Oncol. 2006 Sep;29(3):637-42.
We recently showed, using a parental double B16 melanoma tumor model that, in the presence of CENU-treated primary tumors, untreated secondary tumors exhibited growth inhibition. This response was shown to be related to CENU-induced bystander effects. To see whether CENU-induced bystander effects were still effective on non-parental syngeneic secondary tumors, Lewis lung (3LL) secondary tumors were inoculated in recipients bearing CENU-treated B16 melanoma tumors. Our results show that non-parental secondary 3LL tumors underwent growth inhibition, differentiation, and phospholipid metabolism alterations, all changes similar to those of parental secondary 3LL tumors. This demonstrates the lack of tumor tissue specificity of chemotherapy-induced bystander effects.
我们最近使用亲本双B16黑色素瘤肿瘤模型表明，在经CENU处理的原发性肿瘤存在的情况下，未经处理的继发性肿瘤表现出生长抑制。这种反应被证明与CENU诱导的旁观者效应有关。为了观察CENU诱导的旁观者效应是否对非亲本同基因继发性肿瘤仍然有效，将Lewis肺癌（3LL）继发性肿瘤接种到携带经CENU处理的B16黑色素瘤肿瘤的受体中。我们的结果表明，非亲本继发性3LL肿瘤经历了生长抑制、分化和磷脂代谢改变，所有这些变化与亲本继发性3LL肿瘤相似。这证明了化疗诱导的旁观者效应缺乏肿瘤组织特异性。
