Morra M
Nobil Bio Ricerche, Str. S. Rocco 36, 14018 Villafranca d'Asti, Italy.
Eur Cell Mater. 2006 Jul 24;12:1-15. doi: 10.22203/ecm.v012a01.
This paper reviews current approaches to the enhancement of bone regeneration at the interface with implant devices, by immobilization of biomolecules to titanium surfaces. In particular, techniques based on surface linking of peptides or extracellular matrix (ECM) proteins are reviewed, trying to describe surface modification approaches and to present results of chemico-physical and biological evaluations, both in vitro and in vivo. Based on existing literature, surface modification by peptides or ECM proteins appears as an effective way to stimulate bone regeneration over that provided by titanium, as suggested by basic studies and in vitro results and confirmed by in vivo findings.
本文综述了通过将生物分子固定在钛表面来增强植入装置界面处骨再生的当前方法。特别地，对基于肽或细胞外基质（ECM）蛋白的表面连接技术进行了综述，试图描述表面修饰方法，并呈现体外和体内化学物理及生物学评估的结果。基于现有文献，肽或ECM蛋白进行的表面修饰似乎是一种比钛本身更有效地刺激骨再生的方法，基础研究和体外结果表明了这一点，体内研究结果也证实了这一点。
