Department of Orthopedics, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
Trends Biotechnol. 2013 Mar;31(3):169-76. doi: 10.1016/j.tibtech.2012.12.004. Epub 2013 Jan 5.
Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration. Moreover, appropriately prepared ECM is biodegradable and does not elicit adverse immune responses. Successful clinical application of decellularized tissues has been reported in cardiovascular, gastrointestinal, and breast reconstructive surgery. At present, the use of ECM for osteochondral tissue engineering is attracting interest. Recent data underscore the great promise for future application of decellularized ECM for osteochondral repair. This review describes the rationale for using ECM-based approaches for different regenerative purposes and details the application of ECM for cartilage or osteochondral repair.
基于脱细胞细胞外基质 (ECM) 支架和组织的再生医学方法正在迅速发展。使用 ECM 作为天然生物材料的原理是存在生物活性分子，这些分子可驱动组织稳态和再生。此外，适当制备的 ECM 是可生物降解的，不会引起不良的免疫反应。脱细胞组织在心血管、胃肠道和乳房重建手术中的成功临床应用已有报道。目前，ECM 用于骨软骨组织工程的应用引起了人们的兴趣。最近的数据强调了脱细胞 ECM 在骨软骨修复中的未来应用的巨大潜力。本文综述了基于 ECM 的方法用于不同再生目的的基本原理，并详细介绍了 ECM 在软骨或骨软骨修复中的应用。
