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溴化银纳米颗粒/聚合物复合材料:双作用可调谐抗菌材料。

Silver bromide nanoparticle/polymer composites: dual action tunable antimicrobial materials.

作者信息

Sambhy Varun, MacBride Megan M, Peterson Blake R, Sen Ayusman

机构信息

Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

出版信息

J Am Chem Soc. 2006 Aug 2;128(30):9798-808. doi: 10.1021/ja061442z.

Abstract

We present a simple method of fabricating highly potent dual action antibacterial composites consisting of a cationic polymer matrix and embedded silver bromide nanoparticles. A simple and novel technique of on-site precipitation of AgBr was used to synthesize the polymer/nanoparticle composites. The synthesized composites have potent antibacterial activity toward both gram-positive and gram-negative bacteria. The materials form good coatings on surfaces and kill both airborne and waterborne bacteria. Surfaces coated with these composites resist biofilm formation. These composites are different from other silver-containing antibacterial materials both in the ease of synthesis and in the use of a silver salt nanoparticle instead of elemental silver or complex silver compounds. We also demonstrate the ability to tune the release of biocidal Ag(+) ions from these composites by controlling the size of the embedded AgBr nanoparticles. These composites are potentially useful as antimicrobial coatings in a wide variety of biomedical and general use applications.

摘要

我们提出了一种制备由阳离子聚合物基质和嵌入的溴化银纳米颗粒组成的高效双效抗菌复合材料的简单方法。采用一种简单而新颖的溴化银原位沉淀技术来合成聚合物/纳米颗粒复合材料。合成的复合材料对革兰氏阳性菌和革兰氏阴性菌均具有强大的抗菌活性。这些材料能在表面形成良好的涂层,杀死空气传播和水传播的细菌。涂覆有这些复合材料的表面可抵抗生物膜形成。这些复合材料在合成的简便性以及使用银盐纳米颗粒而非元素银或复合银化合物方面,与其他含银抗菌材料有所不同。我们还展示了通过控制嵌入的溴化银纳米颗粒的尺寸来调节这些复合材料中杀菌性银离子释放的能力。这些复合材料在各种生物医学和通用应用中作为抗菌涂层具有潜在用途。

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