Ben-Shlomo Gil, Belokopytov Mark, Rosner Mordechai, Dubinsky Galina, Belkin Michael, Epstein Yoram, Ofri Ron
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, 76100 Rehovot, Israel.
Lasers Surg Med. 2006 Aug;38(7):689-94. doi: 10.1002/lsm.20351.
To determine the threshold for electrophysiological detection of functional changes after laser photocoagulation in rats, and to correlate the functional damage with retinal morphology.
STUDY DESIGN/MATERIALS AND METHODS: Argon-laser lesions, covering a quarter or half of the retina, were produced in the right eyes of 25 rats. Eyes were evaluated by flash electroretinography (ERG) and histologically at 3, 21, and 60 days after lasering.
Lasering of half the retina, but not of a quarter, produced a significant decrease in signals at all time points. Some functional recovery was evident 60 days after injury, and was consistent with concurrent morphological healing.
In rats, lasering of half the retina, but not a quarter, leads to significant deficits in outer retinal functions over a 2-month period. Thereafter some recovery occurs, presumably as a result of migration of photoreceptors from undamaged areas and their retinal remodeling.
确定大鼠激光光凝后功能变化的电生理检测阈值，并将功能损伤与视网膜形态相关联。
研究设计/材料与方法：对25只大鼠的右眼进行氩激光损伤，损伤范围覆盖视网膜的四分之一或二分之一。在激光照射后3天、21天和60天，通过闪光视网膜电图（ERG）和组织学方法对眼睛进行评估。
视网膜二分之一区域的光凝，而非四分之一区域的光凝，在所有时间点均导致信号显著降低。损伤60天后有明显的功能恢复，且与同时期的形态学愈合一致。
在大鼠中，视网膜二分之一区域的光凝，而非四分之一区域的光凝，会在2个月内导致视网膜外层功能出现显著缺陷。此后会出现一些恢复，推测是由于光感受器从未受损区域迁移及其视网膜重塑的结果。
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