Belokopytov Mark, Ben-Shlomo Gil, Rosner Mordechai, Belkin Michael, Dubinski Galina, Epstein Yoram, Ofri Ron
Goldschleger Eye Research Institute, Tel-Aviv University, Sheba Medical Center, 52621 Tel HaShomer, Israel.
Lasers Surg Med. 2008 Mar;40(3):196-201. doi: 10.1002/lsm.20610.
To functionally evaluate the efficacy of glatiramer acetate (Cop-1) as a neuroprotective treatment for laser-induced retinal injuries in rats.
STUDY DESIGN/MATERIALS AND METHODS: Using standard lasering and flash ERG techniques, we evaluated the effect of photocoagulation and of Cop-1 treatment on retinal function 3, 20, and 60 days after covering one-half of the retina with of 23 rats with argon laser lesions.
Significant neuroprotective effects of Cop-1 treatment on functional recovery were observed 20 and 60 days after retinal photocoagulation. Two months post-lasering, the amplitude of electroretinographic signals in lasered eyes (mean+/-SEM) was 99.5+/-10.2% of that of intact eyes in the Cop-1-treated group and 85.8+/-5.5% in the untreated lasered control group (P<0.05).
Cop-1 immunization in rats is neuroprotective against laser-induced injuries to the outer retina and improves functional recovery of the injured retina. Studies have documented effective neuroprotective treatment after laser damage to myelinated neurons, but this is the first report of neuroprotection of nonmyelinated neurons.
从功能上评估醋酸格拉替雷（Cop-1）对大鼠激光诱导视网膜损伤的神经保护治疗效果。
研究设计/材料与方法：采用标准激光照射和闪光视网膜电图（ERG）技术，我们对23只大鼠用氩激光损伤视网膜一半后3天、20天和60天，评估光凝和Cop-1治疗对视网膜功能的影响。
视网膜光凝后20天和60天观察到Cop-1治疗对功能恢复有显著的神经保护作用。激光照射后两个月，Cop-1治疗组激光照射眼视网膜电图信号幅度（均值±标准误）为正常眼的99.5±10.2%，未治疗的激光照射对照组为85.8±5.5%（P<0.05）。
大鼠Cop-1免疫对激光诱导的视网膜外层损伤具有神经保护作用，并能改善受损视网膜的功能恢复。已有研究记录了激光损伤有髓神经元后的有效神经保护治疗，但这是关于无髓神经元神经保护的首次报道。
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