Kuleshova E P, Merghanova G Kh, Kulikov M A, Grigor'ian G A
Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 May-Jun;56(3):392-400.
A blockade of the dopaminergic D1/D2 receptors by systemic administration of haloperidol (0.05-0.5 mg/kg) produced a dose-dependent increase in inhibition of conditioned alimentary behavior in cats under conditions of choice between a valuable delayed reward and a less valuable immediate reward. Administration of haloperidol produced a progressive decrease in the number of effective instrumental reactions, but did not affect the choice between short- and long-latency reactions and their mean latencies. The data obtained do not support a hypothesis that the blockade of dopaminergic receptors shifts behavior towards impulsive reactions. The reasons why the results do not support the hypothesis are discussed.
通过全身给予氟哌啶醇(0.05 - 0.5毫克/千克)阻断多巴胺能D1/D2受体,在猫面对有价值的延迟奖励和价值较低的即时奖励之间进行选择的条件下,对条件性进食行为的抑制产生了剂量依赖性增加。给予氟哌啶醇使有效工具性反应的数量逐渐减少,但不影响短潜伏期和长潜伏期反应之间的选择及其平均潜伏期。所获得的数据不支持多巴胺能受体阻断会使行为转向冲动反应的假说。讨论了结果不支持该假说的原因。