Kords H
Z Geburtshilfe Perinatol. 1975 Feb;179(1):40-4.
CAMP levels of isolated rat uteri (2nmol/g wwt) were increased by Fenoterol (10(-4)--1 mug/ml) in a dose dependent manner reaching concentrations of more than 10nmol/g withing 2--5 min. AT 2 TIMES 10(-3) MUG/ML Fenoterol inhibited spontaneous contractions of the rat uterus in vitro. A 10,000 fold higher dosis of Fenoterol was needed to elicit a similar degree of inhibition, when contractions were induced by 0.6 mU/ml Oxytocin. However cAMP levels were elevated by Fenoterol in presence of Oxytocin, uterine contractions were not inhibited, i.e. the elevation of cAMP after administration of Fenoterol is correlated with a relaxant effect only in uteri contracting spontaneously.
离体大鼠子宫的环磷酸腺苷（CAMP）水平（2nmol/g湿重），在2 - 5分钟内，可被非诺特罗（10⁻⁴ - 1μg/ml）以剂量依赖方式升高，达到超过10nmol/g的浓度。在2×10⁻³μg/ml时，非诺特罗可抑制大鼠子宫的体外自发收缩。当由0.6mU/ml催产素诱导收缩时，需要高10000倍剂量的非诺特罗才能引起相似程度的抑制。然而，在催产素存在的情况下，非诺特罗可使环磷酸腺苷水平升高，但子宫收缩并未受到抑制，即非诺特罗给药后环磷酸腺苷的升高仅与自发收缩子宫的松弛效应相关。
