双酚A二缩水甘油醚（BADGE）及其衍生物在大肠杆菌色氨酸回复突变试验中的致突变作用研究。

Study on mutagenic effects of bisphenol A diglycidyl ether (BADGE) and its derivatives in the Escherichia coli tryptophan reverse mutation assay.

作者信息

Sueiro Rosa Ana, Suárez Susanna, Araujo Manuel, Garrido Manuel Joaquín

机构信息

Laboratorio de Microbioloxía, Instituto de Investigación e Análises Alimentarias, Universidade de Santiago de Compostela, Campus Sur s/n, 15782 Santiago de Compostela, Spain.

出版信息

Mutat Res. 2006 Oct 10;609(1):11-6. doi: 10.1016/j.mrgentox.2006.05.012. Epub 2006 Jul 25.

DOI:10.1016/j.mrgentox.2006.05.012

PMID:16870492

Abstract

The di-epoxy compound bisphenol A diglycidyl ether (BADGE), its first and second hydrolysis products (BADGE.H2O and BADGE.2H2O, respectively) and its bis-chlorohydrin derivative (BADGE.2HCl) were examined for their mutagenicity in the Escherichia coli tryptophan reverse mutation test with strains WP2, WP2uvrA and IC3327. The assays were performed in the presence and absence of exogenous metabolic activation (S9 fraction from rat liver). The di-epoxy compound BADGE was able to induce mutagenic effects in strains WP2uvrA and IC3327 and the epoxy-diol BADGE.H2O also showed a positive response with these strains, although the latter was less potent than the former. On the other hand, the lack of mutagenic activity of BADGE.2H2O and BADGE.2HCl was also demonstrated.

摘要

在使用WP2、WP2uvrA和IC3327菌株的大肠杆菌色氨酸回复突变试验中，检测了二环氧化合物双酚A二缩水甘油醚（BADGE）、其一级和二级水解产物（分别为BADGE.H2O和BADGE.2H2O）及其双氯醇衍生物（BADGE.2HCl）的致突变性。试验在有和没有外源性代谢活化（大鼠肝脏的S9组分）的情况下进行。二环氧化合物BADGE能够在WP2uvrA和IC3327菌株中诱导致突变效应，环氧二醇BADGE.H2O在这些菌株中也显示出阳性反应，尽管后者的效力低于前者。另一方面，也证明了BADGE.2H2O和BADGE.2HCl缺乏致突变活性。