Sasaguri T, Soejima M, Hino Y, Shiraishi H, Date H, Takasugi M, Tanimoto A, Horie A
Ashiya Municipal Hospital, Fukuoka, Japan.
Jpn J Med. 1991 Sep-Oct;30(5):477-82. doi: 10.2169/internalmedicine1962.30.477.
A 71-year-old woman was clinically suspected of allergic granulomatous angiitis (AGA) because of preceding allergic diseases including bronchial asthma, remarkable eosinophilia (14,300/mm3), mononeuritis multiplex, positive rheumatoid factor, elevated serum immunoglobulin E, and eosinophilic inflammation of the kidney. Autopsy findings, however, were characterized of polyarteritis nodosa (PAN). Necrotizing angiitis was present in several organs except for the lung; focal and segmental glomerular lesions with crescent formation were observed in the kidney, and granuloma formation was not found. This case may be an intermediate type between PAN and AGA (an overlap syndrome) and provide useful information on the clinical entities of systemic necrotizing vasculitis.
一名71岁女性因先前患有包括支气管哮喘在内的过敏性疾病、显著嗜酸性粒细胞增多（14,300/mm³）、多发性单神经炎、类风湿因子阳性、血清免疫球蛋白E升高以及肾脏嗜酸性炎症，临床上怀疑患有过敏性肉芽肿性血管炎（AGA）。然而，尸检结果显示为结节性多动脉炎（PAN）。除肺部外，多个器官存在坏死性血管炎；肾脏观察到局灶性和节段性肾小球病变伴新月体形成，未发现肉芽肿形成。该病例可能是PAN和AGA之间的中间类型（重叠综合征），并为系统性坏死性血管炎的临床实体提供有用信息。
