Iwasaki Y, McMichael J, Koprowki H
Acta Neuropathol. 1975;31(4):315-24. doi: 10.1007/BF00687926.
The pathogenicity of a strain of parainfluenza type 1 virus, isolated from the cultured brain cells from multiple sclerosis patients and designated as 6/94 virus, was studied in mouse brain. Selective degeneration of cerebral white matter, preceded by mononuclear cell infiltration, and ependymitis were prominent pathological features of the mouse intracerebrally inoculated with 6/94 virus. After inactivation by ultraviolet light the virus was still capable of producing the inflammatory and degenerative white matter lesions, although the severity of ependymitis was substantially reduced.
从多发性硬化症患者培养的脑细胞中分离出的一株1型副流感病毒（命名为6/94病毒），其致病性在小鼠脑中进行了研究。接种6/94病毒的小鼠脑内，主要病理特征为单核细胞浸润先于脑白质选择性变性和室管膜炎。经紫外线灭活后，该病毒仍能引起炎症性和退行性白质病变，尽管室管膜炎的严重程度显著降低。
