Tanaka R, Iwasaki Y, Koprowski H
Am J Pathol. 1975 May;79(2):335-46.
The adult mouse inoculated intracerebrally with 6/94 strain of parainfluenza type 1 virus developed selective degenerative lesions in cerebral white matter. Ultrastrucrally, the infiltration of mononuclear cells, mostly lymphoid cells, apparently preceded the alterations of white matter parenchyma. The prominent feature of the white matter lesion was a lytic degeneration of both axon and myelin that seemed to be triggered by the mononuclear cell infiltration. Nucleocapsids of paramyxovirus were found only in ependymal cells and the very early stages of the infection. It is suggested that the mechanism of the white matter degeneration might be that of a virus-induced cell-mediated immune response directed at both the axon and myelin.
用1型副流感病毒6/94株脑内接种成年小鼠后，其脑白质出现选择性退行性病变。超微结构显示，单核细胞（主要是淋巴细胞）的浸润明显先于白质实质的改变。白质病变的突出特征是轴突和髓鞘的溶解性退变，这似乎是由单核细胞浸润引发的。仅在室管膜细胞和感染的极早期发现副粘病毒核衣壳。提示白质退变的机制可能是病毒诱导的针对轴突和髓鞘的细胞介导免疫反应。
