Lewandowski L J, Gerhard W U, Palmer J C
Infect Immun. 1976 Mar;13(3):712-21. doi: 10.1128/iai.13.3.712-721.1976.
Maximum cytotoxicity to parainfluenza type 1 viral determinants occurs on day 5 post-immunization in mice with and without preexisting anti-6/94 virus antibody. Animals with preexisting anti-6/94 serum antibody, however, exhibited a markedly higher cytotoxic response. Syngeneic, allogeneic, and xenogeneic virus-infected cells induce virus-specific cytotoxicity, but only infected cells histocompatible with the effector cells can serve as susceptible target cells. The effector cell is a T cell, and hence cytotoxicity is thymus dependent. Coincident with the maximum cytotoxic activity on day 5 is the occurrence of pathological lesions, the sites of which are dependent on the route of inoculation.
对1型副流感病毒决定簇的最大细胞毒性在免疫后第5天出现在有或没有预先存在的抗6/94病毒抗体的小鼠中。然而，预先存在抗6/94血清抗体的动物表现出明显更高的细胞毒性反应。同基因、异基因和异种病毒感染的细胞可诱导病毒特异性细胞毒性，但只有与效应细胞组织相容性的感染细胞才能作为敏感靶细胞。效应细胞是T细胞，因此细胞毒性是胸腺依赖性的。与第5天的最大细胞毒性活性同时出现的是病理损伤的发生，其部位取决于接种途径。
