Skelton Joseph A, DeMattia Laure, Miller Lawrence, Olivier Michael
Division of Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, 8701 Watertown Plank Road, PO Box 26509, Milwaukee, WI 53226, USA.
Pediatr Clin North Am. 2006 Aug;53(4):777-94. doi: 10.1016/j.pcl.2006.05.011.
Like many diseases, the causes of obesity are complex, and their investigation requires novel approaches. Given the many contributors to our weight status, as well as the dynamic nature, genomic tools must be applied in an ecological model. Evaluating disparate factors can be difficult, such as feeding behavior, nutritional genomics, and gene-environment interaction. Many of these behaviors are being evaluated in animal models and hold great promise for targeted interventions in the future.
与许多疾病一样，肥胖的成因复杂，对其进行研究需要新方法。鉴于影响我们体重状况的因素众多，且具有动态性，基因组工具必须应用于生态模型中。评估不同因素可能具有挑战性，如进食行为、营养基因组学以及基因与环境的相互作用。其中许多行为正在动物模型中进行评估，有望在未来实现有针对性的干预。
