Thureen Dean R, Keeler Calvin L
Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716-2150, USA.
J Virol. 2006 Aug;80(16):7863-72. doi: 10.1128/JVI.00134-06.
Psittacid herpesvirus 1 (PsHV-1) is the causative agent of Pacheco's disease, an acute, highly contagious, and potentially lethal respiratory herpesvirus infection in psittacine birds, while infectious laryngotracheitis virus (ILTV) is a highly contagious and economically significant avian herpesvirus which is responsible for an acute respiratory disease limited to galliform birds. The complete genome sequence of PsHV-1 has been determined and compared to the ILTV sequence, assembled from published data. The PsHV-1 and ILTV genomes exhibit similar structural characteristics and are 163,025 bp and 148,665 bp in length, respectively. The PsHV-1 genome contains 73 predicted open reading frames (ORFs), while the ILTV genome contains 77 predicted ORFs. Both genomes contain an inversion in the unique long region similar to that observed in pseudorabies virus. PsHV-1 is closely related to ILTV, and it is proposed that it be assigned to the Iltovirus genus. These two avian herpesviruses represent a phylogenetically unique clade of alphaherpesviruses that are distinct from the Marek's disease-like viruses (Mardivirus). The determination of the complete genomic nucleotide sequences of PsHV-1 and ILTV provides a tool for further comparative and functional analysis of this unique class of avian alphaherpesviruses.
鹦鹉疱疹病毒1型（PsHV-1）是帕切科氏病的病原体，这是一种在鹦鹉科鸟类中发生的急性、高度传染性且可能致命的呼吸道疱疹病毒感染，而传染性喉气管炎病毒（ILTV）是一种高度传染性且具有重要经济意义的禽疱疹病毒，它会引发仅限于鸡形目鸟类的急性呼吸道疾病。PsHV-1的完整基因组序列已被确定，并与从已发表数据组装的ILTV序列进行了比较。PsHV-1和ILTV基因组表现出相似的结构特征，长度分别为163,025 bp和148,665 bp。PsHV-1基因组包含73个预测的开放阅读框（ORF），而ILTV基因组包含77个预测的ORF。两个基因组在独特的长区域都含有一个类似于在伪狂犬病病毒中观察到的倒位。PsHV-1与ILTV密切相关，有人提议将其归入传染性喉气管炎病毒属。这两种禽疱疹病毒代表了α疱疹病毒中一个系统发育上独特的进化枝，与马立克氏病样病毒（马立克病毒属）不同。PsHV-1和ILTV完整基因组核苷酸序列的确定为进一步比较和功能分析这类独特的禽α疱疹病毒提供了一个工具。
