Karppanen H, Lahovaara S, Männistö P, Vapaatalo H
Acta Physiol Scand. 1975 Jun;94(2):184-8. doi: 10.1111/j.1748-1716.1975.tb05878.x.
In the present study a comparison was made on the role of the renin-aldosterone system in rats with various forms of experimental hypertension (pinealectomy-induced, renal and spontaneous). The plasma sodium and potassium concentrations as well as renin activity were measured. The in vitro production of aldosterone by quartered adrenal glands of these rats was also determined. 5 weeks after the operations the blood pressure of the pinealectomized and renal operated rats was significantly increased. The plasma sodium concentration did not differ in various groups, but that of potassium was decreased in the renal hypertensive animals. The plasma renin activity of the pinealectomized rats was elevated while in other forms of hypertension it was at the control level. The basal aldosterone production by the adrenal quarters was equal in all the groups. ACTH, dibutyryl cyclic adenosine-3',5'-monophosphate (DBA) and 5HT stimulated the aldosterone production. The responses to ACTH and DBA were greater in the adrenals of renal hypertensive rats than in the other forms of hypertension or in the controls. We suggest that the renin-aldosterone system is of importance in the maintenance of renal hypertension, while in pinealectomy-induced hypertension elevated plasma renin activity reflects an increased sympathetic activity which probably is the main cause of hypertension in these animals.
在本研究中，对肾素 - 醛固酮系统在各种形式实验性高血压大鼠（松果体切除诱导型、肾性和自发性）中的作用进行了比较。测量了血浆钠和钾浓度以及肾素活性。还测定了这些大鼠的四分肾上腺体外醛固酮生成情况。手术5周后，松果体切除和肾手术大鼠的血压显著升高。各实验组的血浆钠浓度无差异，但肾性高血压动物的血浆钾浓度降低。松果体切除大鼠的血浆肾素活性升高，而在其他形式的高血压中，其肾素活性处于对照水平。所有组中肾上腺四分体的基础醛固酮生成量相同。促肾上腺皮质激素（ACTH）、二丁酰环磷腺苷（DBA）和5 - 羟色胺（5HT）刺激醛固酮生成。肾性高血压大鼠肾上腺对ACTH和DBA的反应比其他形式的高血压或对照组更强烈。我们认为，肾素 - 醛固酮系统在维持肾性高血压中起重要作用，而在松果体切除诱导的高血压中，血浆肾素活性升高反映交感神经活性增加，这可能是这些动物高血压的主要原因。
