Bahrampour Juybari Kobra, Pourhanifeh Mohammad Hossein, Hosseinzadeh Azam, Hemati Karim, Mehrzadi Saeed
Department of Pharmacology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Virus Res. 2020 Oct 2;287:198108. doi: 10.1016/j.virusres.2020.198108. Epub 2020 Aug 5.
Viral infections are dangerous diseases for human health worldwide, which lead to significant morbidity and mortality each year. Because of their importance and the lack of effective therapeutic approaches, further attempts should be made to discover appropriate alternative or complementary treatments. Melatonin, a multifunctional neurohormone mainly synthesized and secreted by the pineal gland, plays some roles in the treatment of viral infections. Regarding a deadly outbreak of COVID-19 across the world, we decided to discuss melatonin functions against various viral infections including COVID-19. Therefore, in this review, we summarize current evidence on melatonin therapy for viral infections with focus on possible underlying mechanisms of melatonin actions.
病毒感染是全球范围内对人类健康构成威胁的危险疾病，每年都会导致大量发病和死亡。由于其重要性以及缺乏有效的治疗方法，应进一步努力寻找合适的替代或补充治疗方法。褪黑素是一种主要由松果体合成和分泌的多功能神经激素，在病毒感染的治疗中发挥着一定作用。鉴于新冠病毒在全球范围内的致命性爆发，我们决定探讨褪黑素对包括新冠病毒在内的各种病毒感染的作用。因此，在本综述中，我们总结了目前关于褪黑素治疗病毒感染的证据，重点关注褪黑素作用的可能潜在机制。
