Dubuisson Jean-François, Swanson Michele S
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0620, USA.
Autophagy. 2006 Jul-Sep;2(3):179-82. doi: 10.4161/auto.2831. Epub 2006 Jul 17.
Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of microbes.(1-3) Not surprisingly, to establish a replication niche in host cells, some intracellular pathogens have acquired mechanisms either to evade or subvert the autophagic pathway. Because they are amenable to genetic manipulation, these microbes can be exploited as experimental tools to investigate the contribution of autophagy to immunity. Here we discuss the mouse macrophage response to L. pneumophila, the facultative intracellular bacterium responsible for an acute form of pneumonia, Legionnaire's disease.
自噬是一种保守的膜运输途径，它使真核细胞能够在双膜液泡（即自噬体）中捕获细胞质成分，以便输送到溶酶体。尽管自噬最广为人知的是作为一种在饥饿中存活的机制，但现在人们认识到它还能对抗多种微生物的感染。（1-3）毫不奇怪，为了在宿主细胞中建立复制位点，一些细胞内病原体已经获得了逃避或破坏自噬途径的机制。由于这些微生物易于进行基因操作，因此可以用作实验工具来研究自噬对免疫的贡献。在这里，我们讨论小鼠巨噬细胞对嗜肺军团菌的反应，嗜肺军团菌是一种导致急性肺炎（军团病）的兼性细胞内细菌。
