Lollis S Scott, Weider Dudley J, Phillips Joseph M, Roberts David W
Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
J Neurosurg. 2006 Jul;105(1):1-5. doi: 10.3171/jns.2006.105.1.1.
The goal of this study was to provide preliminary data regarding clinical and functional outcome, including postoperative morbidity, related to ventriculoperitoneal (VP) shunt insertion for refractory perilymphatic fistula.
The authors retrospectively reviewed the records of seven consecutive patients who had undergone VP shunt insertion for medically and surgically refractory perilymphatic fistula between 1996 and 2004. Patients were also contacted by telephone and asked to assess retrospectively their symptomatic improvement, changes in functional status, and changes in work status following shunt placement. Preoperative and postoperative functional statuses were assessed using a standardized instrument. In each patient, preoperative opening pressure was measured via lumbar puncture. Pressures ranged from 160 to 300 mm H2O, with a mean of 241 mm H2O. All patients reported significant improvement in symptom severity following surgery. Two patients reported complete resolution of symptoms. Three patients were able to resume full-time work. Clinically significant improvement in functional status was noted in six of seven patients. All patients would recommend the procedure to others in a similar situation.
Data in this study suggest that some patients with disabling vertigo, tinnitus, and headache due to perilymphatic fistula, whose conventional medical and surgical therapies have failed to produce a cure, benefit from VP shunt insertion. The authors hypothesize that VP shunt placement blunts intracranial pressure increases, which would cause secondary elevations in perilymphatic fluid pressure. Shunt insertion reduces perilymph leakage into the middle ear and may permit closure of the fistula.
本研究的目的是提供有关临床和功能结果的初步数据,包括与难治性外淋巴瘘脑室腹腔(VP)分流术相关的术后发病率。
作者回顾性分析了1996年至2004年间连续7例因药物和手术治疗难治性外淋巴瘘而接受VP分流术的患者记录。还通过电话联系患者,要求他们回顾性评估分流术后症状改善情况、功能状态变化和工作状态变化。使用标准化工具评估术前和术后功能状态。在每位患者中,通过腰椎穿刺测量术前开放压力。压力范围为160至300 mm H2O,平均为241 mm H2O。所有患者术后症状严重程度均有显著改善。2例患者报告症状完全缓解。3例患者能够恢复全职工作。7例患者中有6例功能状态有临床显著改善。所有患者均会向其他处于类似情况的人推荐该手术。
本研究数据表明,一些因外淋巴瘘导致眩晕、耳鸣和头痛致残且传统药物和手术治疗未能治愈的患者,可从VP分流术中获益。作者推测,VP分流术可减轻颅内压升高,而颅内压升高会导致外淋巴液压力继发性升高。分流术可减少外淋巴漏入中耳,并可能使瘘管闭合。