Welch W J
University of California, San Francisco.
Curr Opin Cell Biol. 1991 Dec;3(6):1033-8. doi: 10.1016/0955-0674(91)90125-i.
Recent studies have revealed that protein folding and assembly events in vivo require the participation of accessory components, now being referred to as 'molecular chaperones'. A number of chaperones have been identified as members of the heat-shock (or stress) protein family. This review discusses the roles of two classes of chaperones, the heat-shock protein 70 and groEL/ES families, in facilitating protein maturation, and describes how such events are perturbed in the cell subjected to metabolic stress.
