Nyári Tibor A, Kajtár Pál, Parker Louise
Department of Medical Informatics, University of Szeged, Hungary.
Eur J Cancer. 2006 Sep;42(14):2350-4. doi: 10.1016/j.ejca.2005.12.029. Epub 2006 Jul 31.
In a cohort study we investigated the incidence and distribution of the age and stage of neuroblastoma at diagnosis, and the outcome, in children aged 0-14 years during 1988-1998 in Hungary. The proportion of neuroblastoma in age groups of 0 year old, 1-4 year old, 5-9 year old and 10-14 year old children was 30%, 53%, 12% and 5%, respectively. The proportion of stage 1-2, stage 3-4 and stage 4s cases was 30%, 65% and 3%, respectively. Hungarian data were compared with data reported for other Western European countries. The distribution of age at diagnosis of Hungarian cases was significantly different from France and Germany (p < 0.05), but not different from that of the United Kingdom (UK). However, the proportion of stage 1-2 neuroblastoma was higher in Hungarian children (30%) than that reported in French, German and UK children. The incidence and survival of neuroblastoma in Hungary is broadly comparable to that reported elsewhere in Europe.
在一项队列研究中，我们调查了1988年至1998年间匈牙利0至14岁儿童神经母细胞瘤诊断时的年龄和分期发病率及分布情况，以及预后。0岁、1至4岁、5至9岁和10至14岁年龄组儿童中神经母细胞瘤的比例分别为30%、53%、12%和5%。1至2期、3至4期和4s期病例的比例分别为30%、65%和3%。将匈牙利的数据与其他西欧国家报告的数据进行了比较。匈牙利病例诊断时的年龄分布与法国和德国显著不同（p<0.05），但与英国无差异。然而，匈牙利儿童中1至2期神经母细胞瘤的比例（30%）高于法国、德国和英国儿童报告的比例。匈牙利神经母细胞瘤的发病率和生存率与欧洲其他地方报告的情况大致相当。
