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神经性厌食症青少年患者生存率的提高:瑞典两个女性住院患者全国队列的比较

Improved survival in adolescent patients with anorexia nervosa: a comparison of two Swedish national cohorts of female inpatients.

作者信息

Lindblad Frank, Lindberg Lene, Hjern Anders

机构信息

Division of Psychosocial Factors and Health, Karolinska Institutet, Box 220, 17177 Stockholm, Sweden.

出版信息

Am J Psychiatry. 2006 Aug;163(8):1433-5. doi: 10.1176/ajp.2006.163.8.1433.

Abstract

OBJECTIVE

The authors examined two cohorts of female inpatients with anorexia nervosa a decade apart to determine whether there had been any changes in terms of survival.

METHOD

The Swedish National Registers, which contain information about hospital discharges and deaths for the entire population, were used to investigate differences in mortality. Subjects born between 1958 and 1967 and hospitalized due to anorexia nervosa between 1977 and 1981 (N=564) were compared with subjects born between 1968 and 1977 and hospitalized due to anorexia nervosa between 1987 and 1991 (N=554). The cohorts were followed from first hospital admission until 1992 and 2002, respectively.

RESULTS

Twenty-five deaths (4.4%) were recorded within the cohort hospitalized between 1977 and 1981, and seven deaths (1.3%) occurred in the cohort hospitalized between 1987 and 1991. The hazard ratio of death for the 1977-1981 cohort relative to the 1987-1991 cohort was 3.7.

CONCLUSIONS

Mortality among female patients with anorexia nervosa in hospital care in Sweden has decreased dramatically, which is probably related to the introduction of specialized care units.

摘要

目的

作者对两组间隔十年的神经性厌食症女性住院患者进行了研究,以确定生存率是否发生了变化。

方法

利用瑞典国家登记册(其中包含全体人口的出院和死亡信息)来调查死亡率差异。将1958年至1967年出生且在1977年至1981年因神经性厌食症住院的受试者(N = 564)与1968年至1977年出生且在1987年至1991年因神经性厌食症住院的受试者(N = 554)进行比较。分别对这两组队列从首次入院开始随访至1992年和2002年。

结果

在1977年至1981年住院的队列中记录了25例死亡(4.4%),在1987年至1991年住院的队列中有7例死亡(1.3%)。1977 - 1981年队列相对于1987 - 1991年队列的死亡风险比为3.7。

结论

瑞典接受住院治疗的神经性厌食症女性患者的死亡率显著下降,这可能与专门护理单元的引入有关。

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