在印度南部，莱顿因子V通常与特发性门静脉血栓形成无关。
Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India.
作者信息
Koshy Abraham, Jeyakumari Mary
机构信息
Department of Gastroenterology and Molecular Biology Unit, Institute of Population Health and Clinical Research, St. John's Medical College Hospital, Bangalore - 560 034, India.
出版信息
Indian J Gastroenterol. 2006 May-Jun;25(3):140-2.
BACKGROUND
Factor V Leiden has been reported in 2%-30% of patients with portal vein thrombosis. This wide variation makes it difficult to assess the importance of factor V Leiden as a predisposing factor.
METHODS
Factor V Leiden was determined by restriction fragment length polymorphism in 112 patients with portal vein thrombosis, 104 with deep vein thrombosis and 98 control subjects.
RESULTS
Only 3/112 (3%) patients with portal vein thrombosis had factor V Leiden, compared to 1/98 (1%) controls and 16/104 (15%) with deep vein thrombosis; of these, 3, 1 and 15, respectively, were heterozygous for this mutation.
CONCLUSION
Factor V Leiden contributes little, if at all, to the development of portal vein thrombosis in southern India.
背景
据报道，2% - 30%的门静脉血栓形成患者存在莱顿Ⅴ因子。这种广泛的差异使得难以评估莱顿Ⅴ因子作为易感因素的重要性。
方法
采用限制性片段长度多态性方法对112例门静脉血栓形成患者、104例深静脉血栓形成患者和98例对照者进行莱顿Ⅴ因子检测。
结果
112例门静脉血栓形成患者中仅有3例（3%）存在莱顿Ⅴ因子，而98例对照者中有1例（1%），104例深静脉血栓形成患者中有16例（15%）；其中，分别有3例、1例和15例为此突变的杂合子。
结论
在印度南部，莱顿Ⅴ因子对门静脉血栓形成的发展几乎没有影响。
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