Wilson Sarah L, Poulter Neil R
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, St Mary's Campus, London, W2 1PG UK.
J Hypertens. 2006 Aug;24(8):1457-69. doi: 10.1097/01.hjh.0000239278.82196.a5.
This review explores the blood pressure effects of three non-narcotic analgesics: non-selective non-steroidal anti-inflammatory drugs (NSAID), paracetamol and aspirin. The current evidence suggests that in normotensive, otherwise healthy adults, short-term use (1-2 weeks) of NSAIDs is not associated with a significant increase in blood pressure. Those with existing hypertension are more likely to see a blood pressure elevation, although the magnitude of the effect is less predictable and may vary with age, baseline blood pressure, type of NSAID and concurrent antihypertensive therapy. The magnitude of the blood pressure increase appears to be similar for both NSAIDs and paracetamol, while low-dose aspirin may have more modest effects. In hypertensive adults who experience deterioration of blood pressure control on NSAIDs, there is some, albeit suboptimal, evidence that the blood pressure-raising effects of NSAIDs are less when used in conjunction with dihydropyridine calcium-channel blockers than angiotensin-converting enzyme inhibitors.
非选择性非甾体抗炎药（NSAID）、对乙酰氨基酚和阿司匹林。目前的证据表明，在血压正常、其他方面健康的成年人中，短期（1 - 2周）使用非甾体抗炎药与血压显著升高无关。已有高血压的患者更有可能出现血压升高，尽管这种影响的程度较难预测，且可能因年龄、基线血压、非甾体抗炎药类型和同时进行的抗高血压治疗而有所不同。非甾体抗炎药和对乙酰氨基酚导致的血压升高幅度似乎相似，而低剂量阿司匹林的影响可能较小。在因使用非甾体抗炎药而血压控制恶化的高血压成年人中，有一些（尽管不太理想）证据表明，与血管紧张素转换酶抑制剂相比，非甾体抗炎药与二氢吡啶类钙通道阻滞剂联合使用时，其升高血压的作用较小。
