Dall'Oglio Marcos F, Srougi Miguel, Antunes Alberto A, Crippa Alexandre, Cury José
Division of Urology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
BJU Int. 2006 Aug;98(2):384-7. doi: 10.1111/j.1464-410X.2006.06236.x.
To compare two techniques of open prostatic adenectomy (OPA) for controlling bleeding, as OPA is the most effective surgical method for alleviating obstructive symptoms related to benign prostatic hyperplasia (BPH) but there is always a risk of peri-operative bleeding.
The study comprised a prospective and randomized analysis of 62 men with BPH who consecutively had OPA between January 2002 and September 2004. Two techniques were used: in group 1, patients had the Millin modified retropubic prostatectomy, and in group 2 they had a classical transvesical prostatectomy. Blood loss during and after surgery was analysed.
The median (range) blood loss during surgery was 362 (50-700) and 640 (200-1500) mL for groups 1 and 2, respectively (P = 0.007). The mean (sd) decrease in haemoglobin level from before to 1 day after surgery was 1.76 (0.31) and 3.15 (0.33) g/dL for groups 1 and 2, respectively (P < 0.001). When comparing the first and third days after surgery, there were no further significant decreases in levels for group 1, at 0.15 (0.31) g/dL (P = 0.175), but there was a significant decrease for group 2, at 0.74 (0.33) g/dL (P = 0.031). There was a similar decrease in haematocrit levels. While three patients from group 2 required a blood transfusion, only one from group 1 had to be transfused.
The Millin technique, as modified by one of the present authors, can significantly control bleeding during and after surgery, and reduce transfusion rates, when compared to the classic transvesical prostatectomy.
比较两种开放性前列腺切除术(OPA)控制出血的技术,因为OPA是缓解良性前列腺增生(BPH)相关梗阻症状最有效的手术方法,但围手术期始终存在出血风险。
本研究对2002年1月至2004年9月期间连续接受OPA的62例BPH男性患者进行了前瞻性随机分析。使用了两种技术:第1组患者接受米林改良耻骨后前列腺切除术,第2组患者接受经典经膀胱前列腺切除术。分析了手术期间及术后的失血量。
第1组和第2组手术期间的中位(范围)失血量分别为362(50 - 700)毫升和640(200 - 1500)毫升(P = 0.007)。第1组和第2组术后血红蛋白水平从术前到术后1天的平均(标准差)下降分别为1.76(0.31)克/分升和3.15(0.33)克/分升(P < 0.001)。比较术后第1天和第3天,第1组血红蛋白水平无进一步显著下降,为0.15(0.31)克/分升(P = 0.175),而第2组有显著下降,为0.74(0.33)克/分升(P = 0.031)。血细胞比容水平也有类似下降。第2组有3例患者需要输血,而第1组只有1例需要输血。
与经典经膀胱前列腺切除术相比,由本文作者之一改良的米林技术可显著控制手术期间及术后出血,并降低输血率。