Diamant Michaela, Tushuizen Maarten E
Department of Endocrinology/Diabetes Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
Curr Diab Rep. 2006 Aug;6(4):279-86. doi: 10.1007/s11892-006-0061-4.
Due to global lifestyle changes, obesity (the main driver of type 2 diabetes and cardiovascular disease ) is reaching pandemic proportions. The metabolic syndrome, which is regarded as a prediabetic state, is characterized by a concurrence of interrelated cardiovascular risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and glucose intolerance. Endothelial dysfunction (ED) is common in the metabolic syndrome and is associated with increased risk for T2D and CVD. This review focuses on the mechanisms linking ED to the metabolic syndrome, T2D, and CVD, and the possible therapies that may improve ED and reduce T2D and CVD risk.
由于全球生活方式的改变，肥胖（2型糖尿病和心血管疾病的主要驱动因素）正呈现出大流行的态势。代谢综合征被视为糖尿病前期状态，其特征是同时存在相互关联的心血管危险因素，包括腹部肥胖、胰岛素抵抗、高血压、血脂异常和葡萄糖耐量异常。内皮功能障碍（ED）在代谢综合征中很常见，并且与2型糖尿病和心血管疾病的风险增加相关。本综述重点关注将内皮功能障碍与代谢综合征、2型糖尿病和心血管疾病联系起来的机制，以及可能改善内皮功能障碍并降低2型糖尿病和心血管疾病风险的潜在治疗方法。
Zotero 插件