Tushuizen M E, Nieuwland R, Scheffer P G, Sturk A, Heine R J, Diamant M
Department of Endocrinology/Diabetes Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
J Thromb Haemost. 2006 May;4(5):1003-10. doi: 10.1111/j.1538-7836.2006.01914.x.
A large body of evidence has accumulated indicating a relation between postprandial hyperglycemia and hypertriglyceridemia, and the risk of cardiovascular disease.
We studied possible mechanisms underlying the postprandial proatherogenic state by exposing healthy males to two consecutive high-fat mixed meals.
PATIENTS/METHODS: Seventeen healthy males [age 25.4 +/- 3 years, body mass index 23.6 +/- 2 kg m(-2)] were studied during two randomized visits. During the meal visit, subjects consumed standardized meals (50 g of fat, 55 g of carbohydrates and 30 g of proteins) as breakfast and 4 h later as lunch. During the control visit, subjects remained fasted. Prior to each blood collection (before and every 2 h after the first meal), flow-mediated dilation (FMD) of the brachial artery was measured.
Although within the normal range, postprandial plasma glucose and triacylglycerol concentrations increased significantly, especially after the second meal, as compared with baseline (4.8 +/- 0.3 to 5.4 +/- 0.4, 0.8 +/- 0.2 to 1.7 +/- 0.7 mmol L(-1), respectively; both P < 0.05) and the fasting visit. After the second meal, FMD was significantly impaired (6.9% vs. 3.7%, P < 0.05) whereas oxidized low-density lipoprotein (oxLDL)/LDL cholesterol ratio and malondialdehyde concentrations were markedly elevated (both P < 0.01). Finally, an increase in total microparticle (MP) numbers was observed during the meal visit (P < 0.05).
In healthy males, after two consecutive fat-rich meals, mild elevations in plasma glucose and triacylglycerol were paralleled by impaired FMD, increased markers of oxidative stress and circulating MPs, in particular, after the second meal. These findings may have consequences for subjects with postprandial dysmetabolism, including those with Type 2 diabetes.
大量证据表明餐后高血糖与高甘油三酯血症以及心血管疾病风险之间存在关联。
通过让健康男性连续食用两顿高脂肪混合餐，我们研究了餐后促动脉粥样硬化状态潜在的机制。
患者/方法：在两次随机访视期间对17名健康男性[年龄25.4±3岁，体重指数23.6±2 kg/m²]进行了研究。在用餐访视期间，受试者食用标准化餐食（50克脂肪、55克碳水化合物和30克蛋白质）作为早餐，并在4小时后作为午餐。在对照访视期间，受试者保持禁食。在每次采血前（第一餐后及之后每2小时），测量肱动脉的血流介导的血管舒张功能（FMD）。
尽管处于正常范围内，但与基线水平（分别为4.8±0.3至5.4±0.4、0.8±0.2至1.7±0.7 mmol/L）和禁食访视相比，餐后血浆葡萄糖和三酰甘油浓度显著升高，尤其是在第二餐后（均P<0.05）。第二餐后，FMD显著受损（6.9%对3.7%，P<0.05），而氧化型低密度脂蛋白（oxLDL）/低密度脂蛋白胆固醇比值和丙二醛浓度显著升高（均P<0.01）。最后，在用餐访视期间观察到总微粒（MP）数量增加（P<0.05）。
在健康男性中，连续两顿富含脂肪的餐后，血浆葡萄糖和三酰甘油轻度升高，同时伴有FMD受损、氧化应激标志物增加和循环MP增加，尤其是在第二餐后。这些发现可能对餐后代谢异常患者，包括2型糖尿病患者产生影响。
