REVAL Rehabilitation Research Centre, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
Mult Scler. 2013 Oct;19(12):1556-64. doi: 10.1177/1352458513504252. Epub 2013 Sep 18.
Despite many epidemiological studies examining comorbidity in people with multiple sclerosis (pMS), there are conflicting opinions on whether pMS are at more or less risk of cardiovascular disease (CVD) and the metabolic syndrome compared with the general population. As pMS can now expect longer survival, this as an important question both at an individual and public health level. This study aimed to systematically review the literature linking MS to CVD risks and to the risk factors constituting the metabolic syndrome. This systematic review is based on a comprehensive literature search of six databases (Swemed+, Pubmed, Embase, Cochrane, PEDro and CINAHL). In total 34 studies were identified. Despite the high number of identified papers, only limited and inconsistent data exist on the risk factors of the metabolic syndrome and MS. Overall, the data suggest an increased CVD risk in pMS. From the existing studies it is not clear whether the increased risk of CVD is related to an increased risk of obesity or changes in body composition, hypertension, dyslipidemia or type II diabetes in pMS, indicating the need for future research in the field, if we are to advise pMS adequately in avoiding preventable comorbidity.
尽管有许多流行病学研究探讨了多发性硬化症（pMS）患者的共病情况，但对于 pMS 与普通人群相比，心血管疾病（CVD）和代谢综合征的风险更高还是更低，存在相互矛盾的观点。由于 pMS 的预期寿命现在已经延长，因此这是一个个人和公共卫生层面都很重要的问题。本研究旨在系统地综述将 MS 与 CVD 风险以及构成代谢综合征的风险因素联系起来的文献。本系统综述基于对六个数据库（Swemed+、Pubmed、Embase、Cochrane、PEDro 和 CINAHL）的全面文献检索。共确定了 34 项研究。尽管确定的论文数量很多，但关于代谢综合征和 MS 的风险因素的资料有限且不一致。总体而言，数据表明 pMS 患者的 CVD 风险增加。从现有的研究来看，尚不清楚 CVD 风险的增加是否与肥胖或 pMS 中身体成分、高血压、血脂异常或 II 型糖尿病的变化有关，这表明如果我们要充分建议 pMS 避免可预防的共病，那么该领域需要进一步研究。
