Hardy Richard R
Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Curr Opin Immunol. 2006 Oct;18(5):547-55. doi: 10.1016/j.coi.2006.07.010. Epub 2006 Aug 1.
B-1 (CD5+) B cells constitute a phenotypic and functionally distinct population of B cells in mouse that show enriched expression of autoreactive B-cell antigen receptors and that produce several types of natural autoantibodies. Recently, there has been much progress in this field of research. Evidence has appeared for the existence of distinctive B-cell precursors that preferentially generate B-1 B cells, and the crucial requirement for strong B-cell antigen receptor signaling in the maturation of B-1 B cells has been established. Other work focuses on a phenotypically similar population that lacks CD5, termed 'B-1b', which shows similarities and differences from most CD5+ B cells in both development and function. The relationship of normal B-1 cells with B-cell lymphomas and leukemias continues to be a subject of interest and debate.
B-1（CD5+）B细胞在小鼠中构成了一个表型和功能上独特的B细胞群体，这些细胞显示出自反应性B细胞抗原受体的富集表达，并产生几种类型的天然自身抗体。最近，该研究领域取得了很大进展。有证据表明存在优先产生B-1 B细胞的独特B细胞前体，并且已经确定了B-1 B细胞成熟过程中强烈B细胞抗原受体信号传导的关键要求。其他研究工作集中在一个缺乏CD5的表型相似群体，称为“B-1b”，它在发育和功能上与大多数CD5+ B细胞既有相似之处也有不同之处。正常B-1细胞与B细胞淋巴瘤和白血病的关系仍然是一个备受关注和争议的话题。
