Leavis Helen L, Bonten Marc J M, Willems Rob J L
Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Curr Opin Microbiol. 2006 Oct;9(5):454-60. doi: 10.1016/j.mib.2006.07.001. Epub 2006 Aug 1.
Vancomycin-resistant Enterococcus faecium spread dramatically in hospital settings in the USA in the 1990s and reached endemicity at the turn of the century. Similarly, rising prevalence rates are currently observed in several European countries, with prevalence rates of greater than 10% reported in seven of these. On the basis of multilocus sequence typing (MLST), the population structure of E. faecium was elucidated and the existence of a distinct high-risk enterococcal clonal complex, designated clonal complex-17 (CC17), which is associated with the majority of hospital outbreaks and clinical infections in five continents, was revealed. This complex is correlated with ampicillin and quinolone resistance and with the presence of a putative pathogenicity island. Preliminary MLST data suggest that similar hospital-adapted complexes might also exist in E. faecalis.
耐万古霉素屎肠球菌于20世纪90年代在美国医院环境中急剧传播，并在世纪之交达到地方流行程度。同样，目前在几个欧洲国家也观察到患病率不断上升，其中七个国家报告的患病率超过10%。基于多位点序列分型（MLST），阐明了屎肠球菌的种群结构，并揭示了一种独特的高风险肠球菌克隆复合体的存在，该复合体被命名为克隆复合体-17（CC17），它与五大洲的大多数医院暴发和临床感染有关。这个复合体与氨苄西林和喹诺酮耐药性以及一个假定的致病岛的存在相关。初步的MLST数据表明，粪肠球菌中可能也存在类似的适应医院环境的复合体。
