Nakazato Koichi, Song Hongsun, Waga Toshiaki
Department of Exercise Physiology, Graduate School of Health and Sport Science, Nippon Sport Science University, 7-1-1 Fukasawa, Setagaya-ku, Tokyo 158-0081, Japan.
Exp Anim. 2006 Jul;55(4):383-9. doi: 10.1538/expanim.55.383.
In this study, we investigated whether dietary apple polyphenol (APP) had an effect on adipose weights.Twenty-four Wistar male rats (10 weeks of age) were assigned to three groups: (1) the 5%APP group (diet containing 5% APP, N=8); (2) the 0.5%APP group (diet containing 0.5% APP, N=8); and (3) the control group (N=8) so that average weights of the groups were the same. After a three-week experimental period, adipose tissue weights were measured. Pathological and plasma characteristics were also examined. Retroperitoneal and epididymal adipose tissue weights in the 5%APP group were significantly lower than those of the control (P<0.05). Pathological examination showed that form-like cells were observed only in the control group, suggesting the existence of proliferating pre-adipocytes only in the control group. Lipid-related plasma profiles showed no statistical differences. Dietary polyphenol did not induce any anorectic effects as reported in studies concerning tea polyphenol. We conclude that dietary APP has an anti-adipogenic effect in Wistar rats without any anorectic phenomenon.
在本研究中，我们调查了膳食苹果多酚（APP）是否对脂肪重量有影响。将24只10周龄的雄性Wistar大鼠分为三组：（1）5%APP组（饮食中含5%APP，N = 8）；（2）0.5%APP组（饮食中含0.5%APP，N = 8）；（3）对照组（N = 8），以使各组的平均体重相同。经过为期三周的实验期后，测量脂肪组织重量。还检查了病理和血浆特征。5%APP组的腹膜后和附睾脂肪组织重量显著低于对照组（P<0.05）。病理检查显示，仅在对照组中观察到形似细胞，提示仅在对照组中存在增殖的前脂肪细胞。与脂质相关的血浆指标无统计学差异。与关于茶多酚的研究报道不同，膳食多酚未诱导任何厌食作用。我们得出结论，膳食APP对Wistar大鼠具有抗脂肪生成作用，且无任何厌食现象。
