Salas José A, Méndez Carmen
Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain.
Trends Microbiol. 2007 May;15(5):219-32. doi: 10.1016/j.tim.2007.03.004. Epub 2007 Apr 6.
Bioactive natural products are frequently glycosylated with saccharide chains of different length, in which the sugars contribute to specific interactions with the biological target. Combinatorial biosynthesis approaches are being used in antibiotic-producing actinomycetes to generate derivatives with novel sugars in their architecture. Recent advances in this area indicate that glycosyltransferases involved in the biosynthesis of natural products have substrate flexibility regarding the sugar donor but also, less frequently, with respect to the aglycon acceptor. Therefore, the possibility exists of altering the glycosylation pattern of natural products, thus enabling an increase in the structural diversity of natural products.
生物活性天然产物常常会被不同长度的糖链糖基化，其中糖类有助于与生物靶点发生特异性相互作用。组合生物合成方法正被用于抗生素生产放线菌，以生成结构中带有新型糖类的衍生物。该领域的最新进展表明，参与天然产物生物合成的糖基转移酶在糖供体方面具有底物灵活性，但在苷元受体方面的底物灵活性相对较少。因此，存在改变天然产物糖基化模式的可能性，从而增加天然产物的结构多样性。
