双硫仑，一种对人类癌症和真菌感染具有新潜在治疗用途的老药。

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.

作者信息

Sauna Zuben E, Shukla Suneet, Ambudkar Suresh V

机构信息

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892-4256, USA.

出版信息

Mol Biosyst. 2005 Jul;1(2):127-34. doi: 10.1039/b504392a. Epub 2005 May 26.

DOI:10.1039/b504392a

PMID:16880974

Abstract

Disulfiram, a drug used to treat alcoholism, has recently been indicated to play a primary as well as an adjuvant role in the treatment of many cancers and in the reversal of fungal drug-resistance. This review discusses the molecular mechanism of action of disulfiram and its potential use in the treatment of human cancers and fungal infections.

摘要

双硫仑是一种用于治疗酒精中毒的药物，最近已被证明在许多癌症的治疗以及真菌耐药性逆转中发挥主要和辅助作用。本综述讨论了双硫仑的分子作用机制及其在治疗人类癌症和真菌感染中的潜在用途。