Kaul Laurine, Süss Regine, Zannettino Andrew, Richter Katharina
Richter Lab, Department of Surgery, Basil Hetzel Institute for Translational Health Research, University of Adelaide, Adelaide, SA 5011, Australia.
Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg 79104, Germany.
iScience. 2021 Jan 22;24(2):102092. doi: 10.1016/j.isci.2021.102092. eCollection 2021 Feb 19.
Dithiocarbamates (DTCs) have been used for various applications, including as hardening agents in rubber manufacturing, as fungicide in agriculture, and as medications to treat alcohol misuse disorder. The multi-faceted effects of DTCs rely mainly on metal binding abilities and a high reactivity with thiol groups. Therefore, the list of potential applications is still increasing, exemplified by the US Food and Drug Administration approval of disulfiram (Antabuse) and its metabolite diethyldithiocarbamate in clinical trials against cancer, human immunodeficiency virus, and Lyme disease, as well as new DTC-related compounds that have been synthesized to target diseases with unmet therapeutic needs. In this review, we will discuss the latest progress of DTCs as anti-cancer agents and provide a summary of the mechanisms of action. We will explain the expansion of DTCs' activity in the fields of microbiology, neurology, cardiology, and ophthalmology, thereby providing evidence for the important role and therapeutic potential of DTCs as innovative medical treatments.
二硫代氨基甲酸盐（DTCs）已被用于多种用途，包括作为橡胶制造中的硬化剂、农业中的杀菌剂以及治疗酒精滥用障碍的药物。DTCs的多方面作用主要依赖于其金属结合能力和与硫醇基团的高反应活性。因此，其潜在应用的清单仍在不断增加，例如美国食品药品监督管理局批准双硫仑（戒酒硫）及其代谢物二乙基二硫代氨基甲酸盐用于针对癌症、人类免疫缺陷病毒和莱姆病的临床试验，以及为满足未满足的治疗需求而合成的新型DTC相关化合物。在本综述中，我们将讨论DTCs作为抗癌药物的最新进展，并总结其作用机制。我们将解释DTCs在微生物学、神经学、心脏病学和眼科领域活性的扩展，从而为DTCs作为创新医学治疗方法的重要作用和治疗潜力提供证据。
