Noh L M, Hussein S H, Sukumaran K D, Rose I, Abdullah N
Department of Paediatrics, General Hospital Kuala Lumpur, Malaysia.
J Clin Lab Immunol. 1991 Jun;35(2):89-93.
A case of chronic mucocutaneous candidiasis in a Malaysian child who subsequently developed disseminated tuberculosis and toxoplasmosis is described. The phenotype of her peripheral blood mononuclear cells showed discordance for her T cell markers. The presence of a subpopulation of CD2-/CD3+ mononuclear cells leading to an immunodeficiency state is consistent with failure of activation of CD2-mediated alternative pathway resulting in immunodeficiency. Such abnormal CD2-/CD3+ subpopulations have been described in lepromatous leprosy and foetal abortuses.
