Sen Ismail, Constable Peter D, Marshall Tessa S
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey.
Am J Vet Res. 2006 Aug;67(8):1377-84. doi: 10.2460/ajvr.67.8.1377.
To determine and compare the abomasal emptying rates in calves suckling milk replacer or an isotonic or hypertonic solution of NaHCO(3) or glucose.
5 male Holstein-Friesian calves that were < 30 days of age.
Calves were fed 2 L of milk replacer or isotonic (300 mOsm/L) or hypertonic (600 mOsm/L) solutions of NaHCO(3) or glucose containing acetaminophen (50 mg/kg). Venous blood samples and transabdominal ultrasonographic abomasal dimensions were obtained periodically after feeding, and abomasal luminal pH was continuously monitored by placement of a luminal pH electrode through an abomasal cannula. Abomasal emptying rate was assessed by the time to maximal plasma acetaminophen concentration, ultrasonographic determination of the half-time of abomasal emptying, and the time for luminal pH to return to within 1 pH unit of the preprandial value.
Hypertonic NaHCO(3) solution was emptied slower than an isotonic NaHCO(3) solution, isotonic glucose solution was emptied slower than an isotonic NaHCO(3) solution, and hypertonic glucose solution emptied slower than an isotonic glucose solution.
An electrolyte solution for oral administration with a high osmolarity and glucose concentration may lead to a slower resuscitation of dehydrated diarrheic calves because such solutions decrease the abomasal emptying rate and therefore the rate of solution delivery to the small intestine. Whether slowing of the abomasal emptying rate in dehydrated diarrheic calves suckling an oral electrolyte solution is clinically important remains to be determined.
测定并比较人工代乳品或等渗或高渗碳酸氢钠（NaHCO₃）或葡萄糖溶液喂养的犊牛皱胃排空率。
5头年龄小于30日龄的雄性荷斯坦 - 弗里生犊牛。
给犊牛饲喂2升人工代乳品或含对乙酰氨基酚（50毫克/千克）的等渗（300毫渗量/升）或高渗（600毫渗量/升）碳酸氢钠或葡萄糖溶液。喂食后定期采集静脉血样并经腹超声测量皱胃尺寸，通过皱胃插管放置腔内pH电极持续监测皱胃腔内pH值。通过达到最大血浆对乙酰氨基酚浓度的时间、超声测定皱胃排空半衰期以及腔内pH值恢复到餐前值1个pH单位范围内的时间来评估皱胃排空率。
高渗碳酸氢钠溶液排空比等渗碳酸氢钠溶液慢，等渗葡萄糖溶液排空比等渗碳酸氢钠溶液慢，高渗葡萄糖溶液排空比等渗葡萄糖溶液慢。
高渗透压和高葡萄糖浓度的口服电解质溶液可能导致脱水腹泻犊牛复苏较慢，因为此类溶液会降低皱胃排空率，进而降低溶液输送至小肠的速率。脱水腹泻犊牛饮用口服电解质溶液时皱胃排空率减慢在临床上是否重要仍有待确定。
