Minciullo P L, Patafi M, Giannetto L, Ferlazzo B, Trombetta D, Saija A, Gangemi S
Division and School of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina, Messina, Italy.
J Clin Pharm Ther. 2006 Aug;31(4):385-7. doi: 10.1111/j.1365-2710.2006.00738.x.
Benzoyl peroxide (BP) is commonly used for topical acne treatment and has long been known to be a weak allergen and a strong irritant. We report a case of a 26-year-old woman, who presented with an itchy erythematous reaction and strong oedema localized to the face. Two weeks before angioedema, the patient had started a new topical treatment with a gel containing 10% BP for acne. She was patch tested to European Standard Series, including BP 1% in white petrolatum, and to the 10% BP-containing gel previously used by herself, showing positivity on day 2 to BP 1% and to the 10% BP-containing gel. Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch-test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.
过氧化苯甲酰（BP）常用于局部治疗痤疮，长期以来一直被认为是一种弱过敏原和强刺激物。我们报告了一例26岁女性病例，该患者面部出现瘙痒性红斑反应和严重水肿。在血管性水肿出现前两周，患者开始使用一种含10% BP的凝胶进行新的痤疮局部治疗。她接受了欧洲标准系列的斑贴试验，包括白凡士林基质中1%的BP，以及她之前使用的含10% BP的凝胶，结果在第2天显示对1% BP和含10% BP的凝胶呈阳性反应。提示严重血管性水肿反应与外用BP之间存在关联的因素包括斑贴试验中对BP的强烈反应、时间关系、停药后症状完全缓解以及没有其他明确的解释。
