Department of Dermatology, Klinikum Hanau, 63450 Hanau, Germany.
Contact Dermatitis. 2009 Oct;61(4):209-16. doi: 10.1111/j.1600-0536.2009.01603.x.
Patch testing with benzoyl peroxide 1% pet. frequently leads to (weak) positive reactions, often with uncertain clinical relevance.
To describe the pattern of patch tests reactions to benzoyl peroxide and to identify patients at risk of a positive reaction.
Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 1992-2007.
Benzoyl peroxide 1% pet. was tested in 29 758 patients. Weak positive reactions (erythema, infiltration, possibly papules) occurred in 6.5%, and strong positive reactions (erythema, infiltration, vesicles) in 1.3%. According to logistic regression analysis, strong positive reactions to benzoyl peroxide were associated with leg or face dermatitis, work as dental technicians, young age and being female. Patients with atopic dermatitis had a significantly increased risk of weak positive reactions only.
Our analysis confirms that benzoyl peroxide 1% pet. is a problematic patch test preparation. Hence, clinical relevance of reactions to benzoyl peroxide has to be assessed very carefully. Patients with atopic dermatitis are particularly prone to irritant reactions to benzoyl peroxide. True allergic reactions may occur in dental technicians and following the treatment of leg ulcers with highly concentrated benzoyl peroxide in past. In contrast, widely used acne treatments with benzoyl peroxide seems to sensitize only rarely.
用 1%过氧化苯甲酰进行斑贴试验常常会导致（弱阳性）阳性反应，其临床意义往往不确定。
描述过氧化苯甲酰斑贴试验反应的模式，并确定发生阳性反应的高危人群。
对 1992 年至 2007 年皮肤科信息网络（IVDK）的数据进行回顾性分析。
对 29758 例患者进行了 1%过氧化苯甲酰斑试。弱阳性反应（红斑、浸润，可能有丘疹）发生率为 6.5%，强阳性反应（红斑、浸润、水疱）发生率为 1.3%。根据逻辑回归分析，过氧化苯甲酰的强阳性反应与腿部或面部皮炎、牙科技师职业、年轻和女性有关。特应性皮炎患者仅弱阳性反应的风险显著增加。
我们的分析证实 1%过氧化苯甲酰是一种有问题的斑贴试验制剂。因此，必须仔细评估过氧化苯甲酰反应的临床意义。特应性皮炎患者特别容易对过氧化苯甲酰产生刺激性反应。真正的过敏反应可能发生在牙科技师身上，也可能发生在过去腿部溃疡使用高浓度过氧化苯甲酰治疗后。相比之下，广泛应用的过氧化苯甲酰痤疮治疗似乎很少引起过敏。
