Berent R, Auer J, Porodko M, Lamm G, Weber T, Wimmer E, Seier J, Aspöck G, Eber B
Department of Cardiology and Intensive Care, General Hospital Wels, Wels, Austria.
Eur J Cancer Care (Engl). 2006 Jul;15(3):252-6. doi: 10.1111/j.1365-2354.2005.00648.x.
Tumour markers (TM), including alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen (CA) 15-3 and prostate-specific antigen (PSA), are serum markers for malignant diseases. Previous studies investigating the effect of acute and chronic inflammation, cardiopulmonary bypass surgery and cardiopulmonary resuscitation (CPR) on levels of TM showed conflicting results. Cardiopulmonary resuscitation (CPR) may result in a profound inflammatory response, and is frequently associated with severe tissue hypoperfusion. The present study investigated whether AFP, CEA, CA 15-3 and PSA are influenced by CPR. Alpha-fetoprotein (AFP), CEA, CA 15-3 and PSA (only in male patients) were assessed immediately after hospital admission, 6 h, 12 h and 2 days after prolonged CPR in eight male and 12 female patients. Serum levels of AFP, CEA, CA 15-3 did not change significantly after CPR. Prostate-specific antigen (PSA) levels increased significantly with a highest level in the study period 48 h after CPR (3.3 +/- 3.1 and 28.3 +/- 30.5 ng/mL for baseline and 48 h levels, respectively; P < 0.001). Alpha-fetoprotein (AFP), CEA, CA 15-3 and PSA (in men) values above the normal range were observed in 0%, 13.8%, 3.8% and 46.9% of all measurements respectively. At least one value above the normal range were observed in 0%, 20%, 5% and 75% of all patients for AFP, CEA, CA 15-3 and PSA (in men) respectively. Baseline values of AFP, CEA, CA 15-3 and PSA (in men) were above the normal range in 0%, 15%, 5% and 10% of all patients respectively. Levels for all markers did not differ significantly between survivors and non-survivors. In conclusion, prolonged CPR does not influence AFP, CEA, CA 15-3 serum levels, but is frequently associated with increases of PSA. Thus, in contrast to PSA, interpretation of AFP, CEA, CA 15-3 serum levels is not influenced by recent CPR.
肿瘤标志物（TM），包括甲胎蛋白（AFP）、癌胚抗原（CEA）、癌抗原（CA）15 - 3和前列腺特异性抗原（PSA），是恶性疾病的血清标志物。先前关于急性和慢性炎症、体外循环手术及心肺复苏（CPR）对TM水平影响的研究结果相互矛盾。心肺复苏（CPR）可能导致强烈的炎症反应，且常伴有严重的组织灌注不足。本研究调查了AFP、CEA、CA 15 - 3和PSA是否受CPR影响。在8例男性和12例女性患者长时间CPR后的入院即刻、6小时、12小时及2天时，对甲胎蛋白（AFP）、癌胚抗原（CEA）、癌抗原（CA）15 - 3和PSA（仅男性患者）进行评估。CPR后AFP、CEA、CA 15 - 3的血清水平无显著变化。前列腺特异性抗原（PSA）水平显著升高，在CPR后48小时达到最高水平（基线水平和48小时水平分别为3.3±3.1和28.3±30.5 ng/mL；P < 0.001）。在所有测量值中，AFP、CEA、CA 15 - 3和PSA（男性）高于正常范围的值分别为0%、13.8%、3.8%和46.9%。在所有患者中，AFP、CEA、CA 15 - 3和PSA（男性）至少有一个值高于正常范围的分别为0%、20%、5%和75%。AFP、CEA、CA 15 - 3和PSA（男性）的基线值在所有患者中分别有0%、15%、5%和10%高于正常范围。所有标志物的水平在幸存者和非幸存者之间无显著差异。总之，长时间CPR不影响AFP、CEA、CA 15 - 3的血清水平，但常伴有PSA升高。因此，与PSA不同，AFP、CEA、CA 15 - 3血清水平的解读不受近期CPR的影响。
